The area occupied by Guinea today was included in several large West African political groupings, including the Ghana, Mali, and Songhai empires, at various times from the 10th to the 15th century, when the region came into contact with European commerce. Guinea's colonial time began with French military penetration into the area in the mid-19th century. French domination was assured by the defeat in 1898 of the armies of Almamy Samory Touré, warlord and leader of Malinke descent, which gave France control of what today is Guinea and adjacent areas.

Under Touré, Guinea became a one-party dictatorship, with a closed, socialized economy and no tolerance for human rights, free expression, or political opposition, which was ruthlessly suppressed. Originally credited for his advocacy of cross-ethnic nationalism, Touré gradually came to rely on his own Malinke ethnic group to fill positions in the party and government. Alleging plots and conspiracies against him at home and abroad, Touré's regime targeted real and imagined opponents, imprisoning many thousands in Soviet-style prison gulags, where hundreds perished. The regime's repression drove more than a million Guineans into exile, and Touré's paranoia ruined relations with foreign nations, including neighboring African states, increasing Guinea's isolation and further devastating its economy. Sékou Touré and the PDG remained in power until his death on April 3, 1984, when a military junta headed by then-Lt. Col. Lansana Conte seized power.